Anti-24P4C12 (clone Ha5-l(5)2.1)-VC-MMAE ADC

Anti-24P4C12 (clone Ha5-l(5)2.1)-VC-MMAE ADC


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Place of Origin
U.S.A
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Keyword
adc
Category
Pharmaceuticals
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Creative Biolabs

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BIZ
Country / Year Established
U.S.A U.S.A / 2005
Business type
Manufacturer
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Product name Anti-24P4C12 (clone Ha5-l(5)2.1)-VC-MMAE ADC Certification -
Category Pharmaceuticals Ingredients -
Keyword adc Unit Size -
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origin U.S.A Stock -
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Product Information

 

This ADC product is comprised of an anti-24P4C12 monoclonal antibody (clone Ha5-l(5)2.1)) conjugated via a VC linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death. Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood. Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest. Binds to tubulins, interrupts microtubule dynamics. 

 

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Creative Biolabs

Country / Year Established
U.S.A U.S.A / 2005
Membership
BIZ
Business type
Manufacturer

8

DUNS

President
Mr
Address
SUITE 203, 17 Ramsey Road, Shirley, NY 11967, USA
Product Category
Other Pharmaceutical Chemicals
Year Established
2005
Company introduction

 

Creative Biolabs is a leading company of recombinant antibody (rAb) discovery and manufacturing, providing high quality service to customers in academia and industry fields all over the world.
 
Our cutting-edge hybridoma development and phage display platforms allow the production of the most comprehensive list of recombinant antibody products and extensive service portfolio at the most competitive price. Our products range from antibody / peptide libraries, Biosimilar cell lines, Chimeric antigen receptor (CAR) products, antibody-drug conjugates (ADCs) to engineered antibodies such as therapeutic antibodies, nanobodies, bispecific antibodies and intrabodies. We also provide professional custom antibody discovery and engineering services, featuring phage display library construction, antibody humanization, chimerization, engineered antibody production (Fab, scFc, tribody, bispecific antibody, nanobody, minibody, etc.), antibody labeling, hybridoma/stable cell line development, membrane protein production and cGMP-manufacturing which enable larger scale antibody production for development of animal-based assays and clinical trials.

 

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